Effects of Ginger (Zingiber officinale Roscoe) on Type 2 Diabetes Mellitus and Components of the Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

نویسندگان

  • Jie Zhu
  • Hao Chen
  • Zhixiu Song
  • Xudong Wang
  • Zhenshuang Sun
چکیده

Objective This article aims to assess the effects of ginger (Zingiber officinale Roscoe) on type 2 diabetes mellitus (T2DM) and/or components of the metabolic syndrome (MetS). Methods Electronic literature was searched in PubMed, Embase, the Cochrane Library, Chinese Biomedical Database, China National Knowledge Infrastructure, and Wanfang Database from inception of the database to May 19, 2017, and supplemented by browsing reference lists of potentially eligible articles. Randomized controlled trials on research subjects were included. Data were extracted as a mean difference (MD) and 95% confidence interval (CI). Subgroup analysis of fasting blood glucose (FBG) was performed. Results 10 studies met the inclusion criteria with a total of 490 individuals. Ginger showed a significant beneficial effect in glucose control and insulin sensitivity. The pooled weighted MD of glycosylated hemoglobin (HbA1c) was -1.00, (95% CI: -1.56, -0.44; P < 0.001). Subgroup analysis revealed that ginger obviously reduced FBG in T2DM patients (-21.24; 95% CI: -33.21, -9.26; P < 0.001). Meanwhile, the significant effects of improvement of lipid profile were observed. Most analyses were not statistically heterogeneous. Conclusion Based on the negligible side effects and obvious ameliorative effects on glucose control, insulin sensitivity, and lipid profile, ginger may be a promising adjuvant therapy for T2DM and MetS.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

A Systematic Review and Meta-Analysis of Randomized Controlled Trials Comparing the Safety of Dapagliflozin in Type 1 Diabetes Patients

Background and Purpose: The dapagliflozin’s safety profile in insulin-treated adult type-1 diabetes mellites (T1DM) patients remains poorly explored. Therefore, this systematic review and meta-analysis compared the risk of all-cause side effects, study discontinuation of participants due to side effects, urinary tract infection (UTI), diabetic ketoacidosis, and hypoglycemia between dapagliflozi...

متن کامل

Effect of Fructose Intake on Metabolic Biomarkers in Adults with Type 2 Diabetes Mellitus: A Systematic Review of Randomized Clinical Trial Studies

Introduction: Fructose is a lipogenic monosaccharide affecting glucose homeostasis and other metabolic biomarkers; however, there is conflicting evidence in this regard. The current systematic review aimed to determine the effects of fructose on metabolic biomarkers in individuals with T2DM using randomized clinical trial studies. Materials and Methods: In this systematic review study, after se...

متن کامل

Calcium and vitamin D supplementation effects on metabolic factors, menstrual cycles and follicular responses in women with polycystic ovary syndrome: A systematic review and meta-analysis

Background: Polycystic ovary syndrome (PCOS) is the most popular endocrine disorder in reproductive age with unknown etiology and many comorbidities. This systematic review focused on the effectiveness of calcium and vitamin D (Ca/ Vit.D) supplementation on metabolic factors, menstrual cycles, and follicular responses in PCOS patients. Methods: Relevant studies were identified from the followi...

متن کامل

Effect of Empagliflozin on Electrolytes and Lipid Profiles in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis

Introduction: Studies examining the effect of Empagliflozin in patients with type 2 diabetes have reported different results regarding the effect of this drug on electrolytes and lipid profiles. This study aimed to evaluate the effect of Empagliflozin on electrolytes and lipid profiles in patients with type 2 diabetes. Materials and Methods: In this systematic meta-analysis, clinical trials pub...

متن کامل

In vitro and in vivo Production of Gingerols and Zingiberene in Ginger Plant (Zingiber officinale Roscoe)

      Ginger plant, Zingiber officinale Roscoe, is an important tropical plant used as spices and well known for its medicinal properties. It has a pungent and aromatic rhizome rich of zingiberen and gingerols. Many secondary metabolites are known to accumulate in the plant cell culture systems. So, in this research, gingerols and zingiberene production of callus cultures were compared...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره 2018  شماره 

صفحات  -

تاریخ انتشار 2018